It's the year 1568 in Berlin, Germany. The Bubonic Plague is still a major hitch in the areas of Europe and no man has found a cure or the reason behind it yet. Deep in one of Berlin's towns lies a Village named Reinhardt where the Plague is most commonly caught. Moving on from that, we introduce our four main characters. All teen Plague Doctors who're Orphans. Being so young and "Naive" the four aren't aware of the dirty secrets that the town is keeping from them. Will they figure it out..?