In the underbelly of New York City, Ethan Carter, a super soldier known as Deathstroke, walks the fine line between justice and vengeance after receiving an experimental serum from Norman Osborn that enhances his strength, speed, and healing abilities. Embracing a life as a mercenary, Ethan faces the notorious Sinister Six as their coordinated attacks threaten the city. Reluctantly teaming up with his long-time rival, Spider-Man, their relationship is tense, but with the stakes higher than ever, they must set aside their differences to thwart the Sinister Six, proving that even the most unlikely allies can become heroes against a common enemy.