Here are a few ingredients that are beneficial and effective in helping minimize calcium oxalate formation in dogs! Potassium Citrate Potassium citrate is the most effective crystal formation inhibitor for calcium oxalate stones. This ingredient has a two-part function. First, it attaches to calcium in the urine, preventing the formation of mineral crystals that can develop into calcium oxalate stones. Second, it acts as an alkaline agent to prevent urine from becoming too acidic, creating an environment less suitable for calcium oxalate stone formation. Potassium citrate is currently the main ingredient used to help prevent calcium oxalate stones in dogs. Magnesium Magnesium also has a two-part function. First, it can lower the risk of stone formation as it bonds with oxalates, which reduces the number of free oxalate ions that can bond with calcium and form stones. Second, it acts as an alkaline agent and prevents the urine from being too acidic. Vitamin B6 Many veterinarians suggest supplementing with vitamin B6 because it increases the metabolism of glyoxylate, a precursor of oxalic acid. Additionally, a deficiency in vitamin B6 can contribute to increased oxalate production. Vitamin E Studies have shown that supplementing with vitamin E can help reduce the ability of calcium oxalate to crystallize in the kidneys. Fenugreek Powder Fenugreek has been found to increase the levels of antioxidants in the kidneys and decrease oxidative stress. A recent study found that animals who had received fenugreek supplementation had significantly less calcification in their kidneys and less total calcium in the kidney tissue compared to untreated animals. Fennel Seed Powder This ingredient has been used as a digestive aid for centuries. Fennel is a natural diuretic that can help minimize the minerals, crystals, and uric acid associated with oxalate stones.