The Grandsons of Hades follows the journey of three cousins Damian, Theo, and Orion who are the sons of powerful Underworld gods. Raised in the mortal world, they navigate the complexities of their divine heritage while facing unique challenges tied to their abilities. Each month, they receive daunting tasks from their grandmother, designed to prepare them for potential conflicts among gods and demigods. As they deal with their powers, relationships, and the looming threat of a crisis in the Underworld, they encounter a new girl, Amara, who unwittingly becomes intertwined in their lives. The brothers must learn to embrace their destinies and stand together against the forces that threaten their family.