A year after the events of The Amazing Spider-Man 3, Peter's life is as good as it's been in a long time: May is healthy, his job is going well, and he and Mary Jane are still going strong. However, when a couple villains target him, including one in a very personal way, his world is threatened in a way he hasn't experienced in a long time. As he is pushed more and more, Peter struggles with a hard question: How far will he go to protect his loved ones?