Izuku Midoriya AKA The Amazing Spider-Man

Swinging from the tall buildings of New York, Spider-Man perches on a close building to get a vantage point over the city. A crackling voice comes over his earpiece.
"Where are you?" The familiar voice echoes over the line. He's not supposed to be live right now, it's too dangerous.

"What are you doing, I thought it was too dangerous to keep the line open?"

"Shut up, it is actually important when you keep disappearing off my map." The voice says, faking annoyance, but Spider-Man has known him long enough to look past the obvious facade, Kacchan was worried. That's never good, if Kacchan is worried then it is actually important. In the background, there is a distant beeping that keeps cutting in and out, what the hell is that?"You need to get back here right now. I don't what is happening but-" The line cuts out.

"Kacchan?" Spider-Man says, no response, "Kacchan!" Still no response, then off in the distance, there is a loud explosion. Quickly shooting a web to a nearby building, Spider-man swings off towards the explosion, an awful feeling pooling up in his stomach. Getting closer to the explosion, as the scenery gets more familiar, the feeling turns toxic. Once Spider-Man lands in front of the half-collapsed burning building his heart drops. That's Kacchan's building.

Or where in a world without quirks, one boy gets powers and has to traverse New York Cities crime pool.

Or or where Izuku is still a dork, but he's the one and only Spider-Man.