Imagine if one day, you woke up and you weren't the only you out there any more; there was somebody else who walked like you, talked like you, who, for all intents and purposes, is you. Well when Dean Winchester finds that pretty girl in the bar is in fact his female counterpart, that just happens. There is another demon-ganking, ass-tapping, crass hunter going by the name Dean. Or rather more so - Deanna.
But in among the confusion that is Deanna and Samantha Winchester and their friendly, if not socially inept, angel friend Cassie, there is something darker that lingers in the shadows. What does God want with both Cas and Cassie even after he's cast them away from Heaven? Surely the Winchesters will have to get down to the bottom of this, or they might just be losing their closest friends... And maybe even each other.