Chou Tzuyu, a quiet and introspective teenager, has always struggled with the mystery of her parents' sudden disappearance. Raised by her aunt Jihyo and uncle Sungbin, Tzuyu is determined to uncover the truth. When she discovers a hidden briefcase belonging to her father, she embarks on a journey that leads her to Genex Labs, a powerful scientific organization owned by Dr. Minatozaki-Sana's father. As she navigates the complexities of her life, Tzuyu's bond with Sana deepens, but a mysterious event at a school field trip changes everything. After being bitten by a genetically altered spider at Genex Labs, Tzuyu begins to experience strange changes she cannot explain. Her secret transformation into Spider-Woman starts a new chapter in her life, one that will bring her closer to the truth about her parents and the dangers lurking around her.
Park Jihyo became the CEO of her late father's company at a relatively young age after his sudden passing. Everything was going relatively smoothly until something happened. She has become cold-hearted and could care less about those around her ever since. All of her recent secretaries have quit after lasting a few days due to the way she treats them. That streak changed with the appearance of L/N Y/N. Both of their lives are thrown into a mess with love, heartbreak, and a journey of finding themselves.