Wilms Tumor

Wilms tumor is a solid kidney tumor that is often found in children under 10 years of age and is approximately 10% malignancy in children. It is most common at the age of three years and approximately 10% is a bilateral lesion. Wilms' tumor was found equally numerous in both sexes and there was no predilection of nation or race. Wilms' tumor may be found in children with aniridia abnormalities, genitalia doubts and Beckwith-Wiedemann syndrome (macroglossia, omphalocele, viseromegaly, neonatal hypoglycemia). One percent of Wilms Tumors are found to be familial and inherited in an autosomal dominant manner. The Wilms tumor oncogene has been localized on the p13 line of chromosome 11.PathologyWilms' tumors are derived from metanephric blastema, therefore these tumors are composed of elements of the blastema, epithelium, and stroma, in different proportions. Sometimes no epithelial or stromal elements appear. In macroscopic preparations it appears as a tumor that can occur locally in expansion through v.renalis or v.glass or through the lymphatic duct. These tumors are often already metaphosed by the time they are found, especially to the lung (85% and liver 10%).
Sumber:Grawitz, Paul, 1850-1932; ahli patologi, Germany.,Wilms, Max, 1867-1918; ahli bedah, Germany.