Nick Marshall and Darcy Maguire have moved in together, and they couldn't be happier. But, when Nick gets a new job at a rival advertising agency, their relationship is tested. Also, Lola the coffee shop girl has returned, intent on getting Nick back. And as if things couldn't get crazier, Nick's daughter Alex has decided to move in with him, leaving him outnumbered in dangerous territory. Will Nick be able to retain his newfound appreciation of the female psyche, or will the girls in his life make him question his understanding of what women really want? Set shortly after the movie's end, all original cast members will play their characters.