Kassia and Maura Valentine are two sisters, hunting the supernatural, who come across a case in Cheyenne, Wyoming, having a little run in with Sam and Dean Winchester, the sons of John and Mary Winchester. Their father, Andy Valentine, and John Winchester used to be hunting partners back before Kassia was born. The four rebellious hunters start off on the wrong foot but when it comes down to the family business, the case has them working together, regardless what they thought of each other. Crazy events come with the lifestyle, but it's nothing like they expected would happen next. The skeletons of the past always come out to play during vulnerability.