Government officials are trying to track down individuals who possess "the endurance chromosome" which enhances their basic survival instincts. They have a better quality of physical health and physical body strength as well as the increased ability to overcome obstacles. Individuals who possess this gene are known as "The Persistent" - they are a danger to the order and control that stems from the governments influence and they must be destroyed, whatever the cost. At a routine doctor's appointment, Cassidy Stark is asked to provide a blood sample to conduct further tests after an abnormal heart rate reading - when the doctor tells her to get out of the city as fast as she can, she dismisses his warning but she soon discovers that her government are hunting down those with a very rare genetic make-up. When the police arrive at her school one morning, claiming that they have reason to believe she is connected to an attempted hit and run, she knows that she is being hunted and that she must run. On her way to safety, she meets Jason, who also possesses the endurance chromosome. He offers to help her reach a safer part of the country where she will be hidden from those tracking her down. Can she use her newly discovered genetic advantage to outsmart those who wish to be in complete control?