nirvana; (in Buddhism) a transcendent state in which there is neither suffering, desire, nor sense of self, and the subject is released from the effects of karma and the cycle of death and rebirth. It represents the final goal of Buddhism. sorrow; a feeling of deep distress caused by loss, disappointment, or other misfortune suffered by oneself or others. insanity; the state of being seriously mentally ill; madnessAll Rights Reserved