Louise Holmes has a lot to live up to. For one, her father is THE Sherlock Holmes, and her Uncle is THE John Watson.
The problem is, Louise doesn't think she inherited any of her father's smarts, or powers of deduction. All her life she's tried to become an over-achiever.
One day, her father, Sherlock Holmes, is found dead floating at the bottom of a waterfall. This sends Louise into depression, and the Watson family into shock.
After the death of her mother years back, Louise doesn't know how to go on. After seeing the sorrow of her cousin, Ivory Watson decides to take Louise in with John and his beloved girlfriend Rosabelle, the journalist he'd met in Puerto Rico.
After a few months, John Watson starts to become erratic, having little to no sanity left. Ivory begins to fall into depression, telling her father he needs to seek help.
With both cousins stressed and depressed, they get into a fight the eventually leads to Louise getting the boot. She now searches for a place to stay.