Sam has visions of a girl running from the same thing that killed their mom, Sam's girlfriend Jess and almost killed their dad. Sam and Dean follow reports of children going missing in England. None of them seem to survive, except one girl who is somehow tied to the Winchesters misfortune. This mystery girl's life is on the line when demons learn she is alive and in contact with Sam and Dean. Will they help her or leave to take care of family issues?