misery
ˈmɪz(ə)ri/
noun
a state or feeling of great physical or mental distress or discomfort.
"people who had brought her nothing but misery"
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mel·an·cho·li·a ˌmelənˈkōlēə/ noun: melancholia deep sadness or gloom; melancholy. a mental condition marked by persistent depression and ill-founded fears.