Sam, Dean, and Castiel catch a case back in good ol' Sioux Falls, South Dakota. Six people have been killed since Sunday and all the bodies have been located near an old abandoned hospital that's been shut down for 20 years. After a bit of discussion they determine the killer is a pureblood werewolf. The only problem with that conclusion is when they scope out the hospital and encounter a whole other brand of supernatural they've never even seen before. They find themselves getting involved into something much bigger than they thought and Dean realizes that Castiel isn't the only profound bond he has in his life.