Ang Noli Me Tángere ay isang nobelang isinulat ni Jose Rizal, at inilathala noong 1887, sa Europa. Hango sa Latin ang pamagat nito na may kahulugang "huwag mo akong salingin (o hawakan)". Sinipi ito mula sa San Juan 20:17 kung saan sinabi ni Hesus kay Maria Magdalena na "Huwag mo akong salingin sapagkat hindi pa ako nakaaakyat sa aking ama.". Mas madalas itong tinatawag na Noli; at ang salin nito sa Ingles ay Social Cancer. Sinundan ito ng El Filibusterismo.)
Noli Me Tángere (Latin for Don't Touch Me ) is a novel written by José Rizal, one of the national heroes of the Philippines, during the colonization of the country by Spain to describe perceived inequities of the Spanish Catholic priests and the ruling government.
Originally written in Spanish, the book is more commonly published and read in the Philippines in either Tagalog or English. Together with its sequel, El Filibusterismo, the reading of Noli is obligatory for high school students throughout the country.