Rebecca Powers was a 22 year old pursuing her Masters' degree at Stanford University. Since she was one of Sam Winchester's friends at college, Becca decides to call him for support after a particularly bad breakup, hoping he'll come around. A short time later (with no call back from Sam), she starts to notice strange things happening, like back when Jess died.
Becca is exposed to the truth about the supernatural world after almost losing her life to a demon. Sam and Dean take Becca along with them on their journey to find their father.
Certain things with Becca are different, that's what Sam notices. The nightmares, the past he knows nothing about, but at times it seems as if she doesn't know either.