Masakit mang isiping may katapusan ang lahat ng bagay sa mundo. Lahat ng kausap mo, kaibigan mo, kamag-anak mo o kahit kasintahan mo, pwedeng magpaalam anumang oras. Pero gano'n talaga eh. Darating ang kamatayan ng isang tao. Whether you like it or not. Fate is so unfair. Kaya napakahirap kalabanin ito. Lalo na kung nakataya ang meron kayo ngayon. Jameson Alvarez, a stage four brain cancer patient that wished to be normal. But he knew that it's too impossible, so he just wished that from the start, nobody knows him. Because after all, he knew, he will leave them. That's when he met Eliza Alexxandra Martinne. A hopeless romantic, and a die hard fan of James Reid. She's so lonely, and thinks that her life is useless. Until she met Jameson. A guys who had wish to be isolated. A girl who just want to have a happy life. What if their lives met? Are their wishes will come true? Even if they knew that their love would be tragic. Because of An Isolated Man.