A murder has hit Holby ED. Jacob Masters has the perfect life as Clinical Nurse Manager in Holby ED and enjoys working alongside the clinical lead of the hospital, Connie Beauchamp. Jacob is clearly drawn and sexually attracted to Connie and she doesn't have the faintest idea about this but when things take a turn for the worst when they find a bloodied candlestick in Resus. Will Jacob be able to resist temptation over Connie? And when they find out that one of their Emergency Department staff has been murdered, will they be able to find out the murderer and stop them from committing another murder? Or will another staff member meet their grisly end?