Harry, Liam, Niall e Zayn são membros de uma das maiores bandas da atualidades, a One Direction. Louis, sob o pseudônimo de T. William, é um dos compositores mais requisitados do meio artístico.
A One Direction, conhecida por sempre escrever as próprias músicas está passando por problemas nesse quesito e sua management decide contratar T. William para escrever, junto aos garotos, seu novo álbum.
Só há um problema: os cinco são amigos de infância que, devido à uma briga ocasionada pelo rompimento do relacionamento de Harry e Louis, seguiram caminhos diferentes.
Harry Styles is a loner with social anxiety and a boring life. His past constantly mocks him and he has a severe self harm addiction that nobody, not even his best friend Zayn, knows about. Louis Tomlinson is the first openly gay member of his town's football (soccer) team and he doesn't want his sexuality to define him. He hates being known as "Louis, the gay one" and he is constantly bullied. He is very insecure about his sexuality and does anything to seem manly, which includes begging Niall and Liam to let him be. Both boys attend the same college. When they meet, their newfound friendship turns out to be great for the both of them. It eventually turns to a relationship. They are both in their own states of Misery.