Emily, Anne, Taylor, and Jane finally move up to high school and go to the school affiliated with their middle school. Now many more problems arise for the four in an attempt to destroy their relationships.
Emily is a very shy 17 year old with extreme social phobia, who can barely leave her house to get groceries without having a meltdown, while Alison is the life of the party and has a lineup of boys just waiting to get a shot with her. What will happen when their paths unexpectedly cross?