After performing an extremely dangerous and unsuccessful exorcism, ex-priest Thomas Langley must now escape the clutches of a demon that now wants his body to control the church. Meanwhile Sadie battles with every inch of her being for self control though she fails every time. The exorcised college graduate falters quickly to the demons spell, having been possessed since she was a toddler. Vessel of the Night alternates between the two characters and leaves one question unanswered. How far will they go to escape the demon, and most importantly, find the light?