Pokémon Adventures: Red, Blue, & Green
The first story shows Red, the protagonist, who gets his Pokédex from Professor Oak to start on his Pokémon journey, collecting Pokémon and battling gym leaders for the eight coveted gym badges. He later meets his rival Blue (Green in Japanese) who, oddly enough, is Oak's own grandson. Later in his journey, he encounters con artist Green (Blue in Japanese), who sells him fake Pokémon items. She has stolen a Squirtle, the one from Oak’s lab and evolved it into a Wartortle.
Later, Oak had been kidnapped by Team Rocket to create a Mewtwo, and Red, Green and Blue arrive at Saffron City to take on the elite of Team Rocket. They manage to defeat Team Rocket and save Oak. Red then travels to the Indigo Plateau to battle his rival Blue, having gained seven badges, but also prevails against the evil bio-weapon Mewtwo and Team Rocket's leader and legendary missing Viridian Gym Leader, Giovanni, on the way. Red later battles Blue in the Pokémon League Championships and emerges victorious, claiming the title of champion of the Pokémon League.
Pokémon Adventures: Yellow
In contrast to the first story, there is a slight increase in violence and original plots, which will be carried onto further storylines. Red has disappeared after receiving a challenge letter sent to him by Bruno of the Elite Four. They plan to lure him to them, so as to get information on Giovanni’s whereabouts. They also needed his Earth Badge. Only Red’s Pikachu, Pika, managed to escape, Red having been encased in ice. Yellow decided to go look for Red, as Red had helped her catch a Rattata to train her in the skills of battling.
Yellow, Blaine, Blue, Green, Bill, Lt. Surge, Koga and Sabrina join forces to bring down the Elite Four together. They found out that Lance’s master plan was to use the Gym Badges and create an amplifying effect at Cerise Island to power up a mysterious Legendary Pokémon and destroy all humans in the world except themselves. They felt that humans and Pokémon were not meant to coexist. Red turned up later at Cerise Island to help Surge and Bill defeat Bruno. It is also revealed that Giovanni was the one who rescued Red from his ice coffin. The trainers send their power to Yellow, and with their combined strength she manages to defeat Lance.
Pokémon Adventures: Gold, Silver & Crystal
The third adventure is based on the Pokémon Gold, Silver, and Crystal, versions of the game. It features the protagonists Gold, Silver and Crystyl, and is centered mostly around the Johto region. In accordance with the games, Team Rocket tries to make a comeback, but instead of being defeated before Gold reaches the Pokémon League (as it happens in the game), Team Rocket actually attacks the League. Also, the main goal in the story is not for Gold or Crystal to collect all the badges, but for Gold, it is to team up with a Cyndaquil and get Totodile back from Silver (who stole it), and for Crystal, it is to complete the Pokédex.
Pokémon Adventures: Ruby & Sapphire
The Ruby & Sapphire Saga is based on the Ruby and Sapphire versions of the game. It features Ruby, (based on Brendan), and Sapphire, (based on May), and their bet to each other: 80 days for Ruby (a Pokémon coordinator, though that title is never mentioned outside the anime) to win all the Contest Ribbons in Hoenn, and for Sapphire, a powerful trainer in her own right, to battle all the Gym Leaders for the 8 badges.
In their travels, they meet new companions like the gym leaders of the Hoenn region and the avid news reporter Maryann and her cameraman Ty (who play a minor role in the games). Team Magma and Team Aqua is introduced here, as they attempt to awaken the legendary Pokémon Groudon and Kyogre to conquer the world, and Ruby and Sapphire take notice after encountering several main members in their journeys. In the end, the gym leaders, Ruby, and Sapphire must protect the Hoenn region together from the awakened Groudon and Kyogre, but importantly, will the two trainers manage to keep their bet and who will come up to the top