Russian researchers in the late 1940s kept five people awake for fifteen days using an experimental gas based stimulant. They were kept in a sealed environment to carefully monitor their oxygen intake so the gas didn't kill them, since it was toxic in high concentrations. This was before closed circuit cameras so they had only microphones and five inch thick glass porthole sized windows into the chamber to monitor them. The chamber was stocked with books, cots to sleep on but no bedding, running water and toilet, and enough dried food to last all five for over a month.
The test subjects were political prisoners deemed enemies of the state during World War II.
Everything was fine for the first five days; the subjects hardly complained having been promised (falsely) that they would be freed if they submitted to the test and did not sleep for 30 days. Their conversations and activities were monitored and it was noted that they continued to talk about increasingly traumatic incidents in their past, and the general tone of their conversations took on a darker aspect after the four day mark.
After five days they started to complain about the circumstances and events that lead them to where they were and started to demonstrate severe paranoia. They stopped talking to each other and began alternately whispering to the microphones and one way mirrored portholes. Oddly they all seemed to think they could win the trust of the experimenters by turning over their comrades, the other subjects in captivity with them. At first the researchers suspected this was an effect of the gas itself...
After nine days the first of them started screaming. He ran the length of the chamber repeatedly yelling at the top of his lungs for three hours straight, he continued attempting to scream but was only able to produce occasional squeaks. The researchers postulated that he had physically torn his vocal cords. The most surprising thing about this behavior is how the other captives reacted to it... or rather didn't react to it. They continued whispering to the microphones until the second of the captives started to scream. The two non-screaming captives took the books apart, smeared page after page with their own feces and pasted them calmly over the glass portholes. The screaming promptly stopped.
So did the whispering to the microphones.
After three more days passed. The researchers checked the microphones hourly to make sure they were working, since they thought it impossible that no sound could be coming with five people inside. The oxygen consumption in the chamber indicated that all five must still be alive. In fact it was the amount of oxygen five people would consume at a very heavy level of strenuous exercise. On the morning of the 14th day the researchers did something they said they would not do to get a reaction from the captives, they used the intercom inside the chamber, hoping to provoke any response from the captives they were afraid were either dead or vegetables.
They announced: "We are opening the chamber to test the microphones; step away from the door and lie flat on the floor or you will be shot. Compliance will earn one of you your immediate freedom."
To their surprise they heard a single phrase in a calm voice response: "We no longer want to be freed."
Debate broke out among the researchers and the military forces funding the research. Unable to provoke any more response using the intercom it was finally decided to open the chamber at midnight on the fifteenth day.
The chamber was flushed of the stimulant gas and filled with fresh air and immediately voices from the microphones began to object. 3 different voices began begging, as if pleading for the life of loved ones to turn the gas back on. The chamber was opened and soldiers sent in to retrieve the test subjects. They began to scream louder than ever, and so did the soldiers when they saw what was inside. Four of the five subjects were still alive, although no one could rightly call the state that any of them in 'life.'
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