The story begins on the morning of October 23, 2077 at the player character's home in Sanctuary Hills, located near the in-game version of Concord, Massachusetts. Wade is at home with Vanessa, and their son Shaun, and their robotic butler, Codsworth. As the player character is preparing for an event at the Veteran's Hall in Cambridge, a representative from Vault-Tec comes to inform them that their family is approved for admittance into Vault 111, the local fallout shelter. Moments later, a news bulletin warns of an incoming nuclear attack, prompting the family to evacuate to the Vault. They enter just as the nuclear bomb explodes. Upon entering the Vault, Wade and his family are tricked into entering cryogenic tubes by the Vault-Tec staff and frozen alive. After an unknown period of time, Wade and Vanessa are re-awakened by two strangers, and Wade witnesses Shaun's kidnapping and their Vanessa's murder. The player is put back into cryogenic sleep, but manages to get free themselves when the life support system malfunctions. The player discovers that they are the sole survivor of Vault 111, and vows to avenge their spouse's death and find Shaun.
Wade, now known Deadpool, heads home to find Sanctuary Hills in ruins. Wade meets a distraught Codsworth, revealing that 210 years have passed since the war. Codsworth suggests that the player character to go to Concord for help, on the way, finding and befriending a named Dogmeat. When the Sole Survivor arrives at Concord, they rescue Preston Garvey—one of the last of the Commonwealth Minutemen—and his band of settlers from a group of raiders. After assisting Garvey and his group, Wade is recommended to travel to Diamond City, a fortified settlement based in the ruins of , where they meet Piper, an intrepid reporter. From there, they learn about a secretive organization called the Institute, terrifying the Commonwealth, kidnapping people from their homes and sometimes replacing them with "synths," synthetic human beings indistinguishable from real humans.
The Sole Survivor seeks out Nick Valentine, a detective based in Diamond City, to locate their son, but soon learns that Valentine went missing two weeks previously. After finding Valentine—who is revealed to be a second-generation ; a sophisticated biomechanical android—the Sole Survivor uncovers the identity of their spouse's killer, a man named Francis Freeman (Instead of Kellogg!). The Sole Survivor tracks down Kellogg and learns from him that Shaun is currently in the Institute. The player kills Kellogg, avenging their spouse's murder, and retrieves a cybernetic implant from his brain, then heads to Goodneighbor to seek help from Doctor Amari—a scientist skilled in neuroscience—to access the dead mercenary's memories. During their hunt for Kellogg, the Survivor also witnesses the Brotherhood of Steel arriving in the Commonwealth with the Prydwen, their mobile airship headquarters, and has the option to travel to Boston Airport to offer their assistance to the Brotherhood in the fight against the Institute.
After viewing Francis's memories, Deadpool is then tasked to go to the Glowing Sea—the ground zero of the nuclear blast shown early in the story—to find Brian Virgil, an ex-Institute scientist, to get help infiltrating the Institute. According to Virgil, the only way to enter or exit the Institute is with a teleportation chip that only Institute Coursers—trained synth killers—possess. Wade must then track down and kill a Courser in order to obtain the chip.
Deadpool tracks down the secretive Railroad organization for assistance decoding the chip. The Railroad is dedicated to rescuing synths from the Institute, believing them to be oppressed by their creators and mistreated by the inhabitants of the Commonwealth. After they decode the chip for Wade, the Railroad asks for their assistance in fighting the Institute, in which Deadpool can accept or decline.
Virgil provides the blueprints for a device to hijack the Institute's Molecular Relay signal and teleport into the Institute using the chip data. Deadpool has the choice to ally with the Minutemen, the Railroad, or the Brotherhood to construct the relay device. The player successfully enters the Institute, where they discover that their son Shaun is now an old man and the director of the Institute. Shaun reveals that he was kidnapped from the Vault as a specimen for synth experiments thanks to his pure pre-war DNA, and that Deadpool remained in stasis for a further sixty years before being awoken again. Shaun later reveals that he is dying of cancer and wishes for the player to take up his role as Institute Director if Wade sides with the Institute and continue the organization's plans for the future of the Commonwealth. However, if the Sole Survivor sides with the Minutemen, Brotherhood of Steel, or the Railroad, Shaun will blame the Sole Survivor for destroying the future's only hope and re-program the latest synth prototype as the Sole Survivor's son. It is the Sole Survivor's decision to either save the latest synth prototype or destroy it along with the Institute.
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Deadpool in Fallout 4
Science FictionImagine, briefly if everyone's FAVORITE Merc with a Mouth was in Fallout. Now stop imagining. It is now a thing. You're welcome.