Frankenstein meets the Wolf Man

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Some four years after the events of The Wolf Man and The Ghost of Frankenstein, two men break into the Talbot family crypt to open the grave of Larry Talbot, seeking valuables buried with him, on the night of a full moon. During the robbery, the thieves remove the wolfsbane buried with Talbot, and he is awakened from death by the full moon shining on his uncovered body. Talbot reflexively grasps the arm of the grave robber with a fur-covered hand, as the cryptkeeper flees.

Talbot is found by police in Cardiff later in the night, with a vicious head wound, and taken to a hospital where he is treated by Dr. Mannering. Talbot slowly comes to understand his situation, but during the full moon, he transforms into the Wolf Man and kills a police constable. The next morning, Mannering realizes his patient had been roaming about, and tries to reason with him, though unable to accept Talbot's explanation of his curse. Dr. Mannering allows Inspector Owen, to question Talbot who becomes violently irate, then is overcome by orderlies and bound to his bed with leather straps. Not believing his story of being a werewolf, the doctor and detective travel to the village of Llanwelly to investigate Talbot and his story. While they are away, Talbot escapes from the hospital, by biting through the restraints with his teeth. Seeking a cure for the curse that causes him to transform into a werewolf with every full moon, Talbot leaves Britain and seeks the gypsy woman Maleva, who has hearsay knowledge of Dr. Frankenstein and opines he may able to help Talbot. Together they travel to the village of Vasaria, where Talbot hopes to find the notes of Dr. Frankenstein in the remains of the his estate, and permanently end his own life through scientific means. The townsfolk want no part of them or their desire to meet with the deceased Frankenstein and rudely order them to leave.

An upset Talbot transforms into the Wolf Man and howls madly, causing the villagers of Vasaria to raise a mob to chase him down. Fleeing toward the ruins of the Frankenstein manse, Talbot falls through the burned-out flooring and into the frozen cellars below. Talbot recovers from his animal state, and wanders around, discovering Frankenstein's Monster frozen in ice and thaws him out with a fire. Finding that the Monster is unable to locate the notes of the long-dead doctor, Talbot seeks out Baroness Elsa Frankenstein the daughter of Ludwig, posing as a potential buyer of the estate, hoping she knows their hiding place. She declines to assist Talbot, but the pair are invited to the "Festival of the New Wine" by the Burgomeister.

During the festival, a performance of the life-affirming folk song Faro-la Faro-Li enrages Talbot as Dr. Mannering arrives. The doctor, having followed him across Europe, converses with Talbot to persuade him to return to Wales before he has another spell. Talbot refuses to go with Mannering, and the Monster crashes the festival. With the Monster revealed, Elsa and Mannering agree to help the villagers rid themselves of the Frankenstein curse forever. The following morning, the couple, with Maleva in tow, meet with Talbot and the Monster at the ruins. Mannering is instantly fascinated by the Monster scientifically, and the Baroness gives the notes to Talbot and the doctor. Mannering studies the notes and learns how to drain all life from both Talbot and the Monster, believing the laboratory can be repaired for the task.

In the meantime, the villagers are dismayed to see crates of instruments arriving for Dr. Mannering to enable the experiment and become restless, knowing nothing of the doings at the ruins. Vazec, the innkeeper details a plan to destroy the dam overlooking the old estate with dynamite and drown all within, ending their troubles in one blow. The Burgomeister dismisses the idea as nothing but a drunken notion, but Vazec is determined and puts his plan into action.

Unfortunately, Dr. Mannering's scientific curiosity to see the Monster at full strength overwhelms his logic, and to Elsa's horror he decides to fully revive it. The experiment coincides on the night of a full moon, and Talbot transforms yet again as the Monster regains his strength (and eyesight); both escape their restraints.

The Monster begins to carry Elsa away, but the Wolf Man attacks him, and she escapes from the castle with Mannering. The Wolf Man and the Monster then engage in a fight until they are both swept away in the flood that results when Vazec dynamites the dam.

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