The asylum. A quite fitting name for the building, in which the hot-headed Elijah, his freedom-loving sister Eleanor and Owen, his best friend and caring doctor of the group, as leaders of the "Risen", a small flock of apocalypse-survivors, have built themselves a secure base. Despite the safe accommodation however, the residents still have to face their own problems and fears. In Ellie's case, the fact, that the current condition of her health prohibits her from leaving the immediate area and the feelings of guilt towards her friends and family tied to this chained state. Owen in the meantime is investigating the strange virus, threatening to erase humanity. But the second, results are starting to show themselves, another problem joins the rotten outside of the fences. The Saviors have targeted the Risen and are now trying to extort resources from them by using threats and provocations, which soon lead up to a war declaration. But what will happen, when their leader Negan finds out about the vaccine?