More than 1 brain cell at a time

Ethan wakes up after the explosion at the end of RE 8.
With the disembodied whispers of the people the Romanian Megamycete had absorbed over the years, he runs from multiple greedy companies after his bioweapon DNA, and befriends the townspeople from outside and around the one that had a large suspicious cult in it once, now turned nearly completely to ash.

And all he can hope for is to possibly see Rose, Mia, and maybe Chris again.

Oh and the Duke shows up there and here too.