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Coffee poisoning, or caffeine overdose, can cause a range of symptoms, including: Mild symptoms: Headache, nausea, vomiting, anxiety, insomnia, dizziness, or irritability Severe symptoms: Convulsions (seizures), rapid heartbeat, irregular heartbeat, breathing trouble, agitation, confusion, hallucinations, diarrhea, fever, increased thirst, increased urination, and muscle twitching Complications: Neurologic changes, tachy-dysrhythmia, ECG changes, hypokalemia, hyperglycemia, acute kidney injury, rhabdomyolysis, and cardiac arrest