I just finished "Me Before You" by Jojo Moyes and it's definitely a novel that leaves a mark on you; hell, it scars.
From the beginning until the end it's beautiful and will make you tear up.
So, unless you have a heart of steel, I would recommend having a whole box of tissues nearby. I went through a whole pack.
This was a definite slow read, by the way. It took me a few days, and not for any particular reason, I just needed process time, I guess. (Very, very intriguing book and the way it was written.)
But, when you're not busy and you're alone... Give it a shot. Rip your heart out.
So - Thank you, Jojo. You are truly a brilliant author and I look up to you in every sense.