On October 9, 2012, Rose's girlfriend, Mieka Reese, gave birth to their son, Derrick Jr.
Rose's agent is former Bulls guard B. J. Armstrong.
Rose is a Christian and has spoken about his faith, saying "God does everything for a reason".He wears a wristband that says "In Jesus' Name I Play"and has several tattoos about his faith.
In 2016, Rose was involved in a federal civil lawsuit to assess whether he and two friends raped an unnamed former girlfriend in August 2013.In the months before the alleged gang-rape, Rose's accuser, referred to as "Jane Doe" in court transcripts, testified that Rose made her uncomfortable by asking her to perform sexual acts for him or to involve other people in their sex life; he would sometimes get angry when she refused.Doe also mentioned that on the day of the incident, she was drugged against her consent, and alternated in and out of consciousness.During the trial, Rose expressed difficulty and uncertainty with the definition of the word "consent".In October 2016, he was found not liable by an eight-member jury.An appeal in 2018 was denied
In 2018, Rose introduced The Rose Scholars, a scholarship program to help students achieve a higher education.
