It has been recorded that many outbreaks of yellow fever from 1668 to 1883 (or 1863?) in the U.S.
The first outbreak started in New York of 1668, America was still a child, living in England's house alone.
England was away on a business trip, so America was left to deal with the outbreak by himself.
That's why Canada would sneak over to England's house to help America deal with the yellow fever.
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The Hetalia Book
FanficThis book contains Headcannons, diaries/journals, facts and such.. And it may contain feels too.. So ready your handkerchief, tissue or whatever you had there..