While Voldemort was crippled (before he got his body back, so start of Goblet of Fire) Wormtail fed him a potion consisting of unicorn blood and nagini's venom.
Both obviously effected him as unicorns blood is cursed and well Nagini is a snake. Therefore e was cursed to forever have a nose like a snake!!
~District_Gryffindor
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Why Voldemort Doesn't Have A Nose (Fandom Questions Series, Book1)
RandomFirst book of series! Many different reasons Voldemort may have lost his nose!!!