In which the surgeons of Seattle Grace, people of Beacon Hills, Demigods, and gods watch as one of their own goes through stress and struggles.
Fem!OC x Jackson Avery
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Ellen Pompeo as Meredith 'Mer' Grey; Twisted Sister #1, "Your practically my sister." James Pickens JR as Richard 'Rich' Webber; The Mentor, "I've known Anne since Melissa was a med student." Sara Ramirez as Callie 'Cal' Torres; The Sister, "Arizona, Mark, and I would like you to be the godmother. If anything were to happen to Arizona and I, we'd like it if you raised Sophia as your own." Jessica Capshaw as Arizona 'Zona' Robbins; The Peds Mentor, "And, you're like a sister to Callie and I. So, what do you say?" Sarah Drew as April 'Aps' Kepner; Sister #5, "I know Liana from summer camp, we're sisters. We share a dad."
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Eric Dane as Mark 'Mar' Sloan; The Best Friend, "Why don't we have a sibling?" Chyler Leigh as Lexie 'Lex' Grey; Sister #4, "I want you to be my maid of honor."
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The Older Brother Figure & Cousin Patrick Dempsey as Derek 'Der' Shephered "I've been there since day one. You're another sister to me. Natalie, Kathleen, Amelia, and all my other sisters have said you're their sister. Kathleen has even threatened to kill Jackson if he hurts you."
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