Luis is working at the lab with Rebecca. He hasn't aged as much as what he looks in the Re4 remake game, he has his hair tied up in a messy ponytail, glasses and wearing a lab coat. Every time he wears his Lab coat he feels completely different that it bothers him very much from wearing it. He feels his memories coming up every time he wears the dam lab coat, memories from when he used to work for umbrella, when he used to work for Los illuminados. It's like little flashes of memories that pop up and repeat over and over again, he can't help but look like he just stares into the abyss just thinking of what he did or what happened while he was there working for them.
All the guilt, the experiments,the people he worked closely with does not leave his mind and hasn't ever since Re4.