Most characters in MHA are unsuitable for loving a synthetic lifeform. However, I have selected these candidates for the position of Mrs. Midoriya. Please note that you are selecting the first to girl Izuku bonds with. If you select a harem maker, I may or may not add more.
Hatsume Mei
Mei is the absolute best possible choice. She literally calls her machines her babies and in every fanfic I read, she flat out doesn't give a damn about what society does and doesn't deem acceptable and that includes polycule. So if you want to make a harem, she's the best bet. Plus, it wouldn't be the first fanfic she built a breast expansion device in. So this pic is 100% possible in Canon.
Toga Himiko
Himiko is as crazy as they come and also a suitable harem maker. Barely. She's crazy enough to go along with the whole "robot children" thing and probably would act like a mom.
Manami Aiba
It's not too difficult to switch her from the wife of Gentle Criminal to his daughter. Not a good harem maker though. If she joined later than it's fine I guess. Her computer skills will definitely come in handy.
Tsutsumi Kaina
Saving Lady Nagant isn't as hard as you think. Izuku is around five years old and has memories of the future. Plus, he worked with temporal equipment before so it's not that far stretch to say he can make her young again. She's not a harem maker though. That said, she would serve as a much appreciated bodyguard.
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My Kids are Killer Robots!
FanficHaving lost his friends, his family, his dream, and now his freedom, Izuku hatches the most outlandish plan to get it all back. Well, not all of it. Kacchan still hates him, his dream is dead, and his mom still disappears. But, Izuku can make his ow...