In late December 2007, just after filming the pilot episode for The Beast, Swayze began to suffer a burning feeling in his stomach caused by a blockage of his bile ducts.[29] Three weeks later, in mid-January 2008, he was diagnosed with Stage IV pancreatic cancer (specifically, intraductal papillary mucinous neoplasm). He traveled to the Stanford University Medical Center for chemotherapy and treatment with the experimental drug Vatalanib, which doctors hoped would cut off the blood supply to the tumor.[30] On March 5, 2008, a Reuters article reported that Swayze "has a very limited amount of disease, and he appears to be responding well to treatment thus far."[31] Swayze's doctor confirmed that the actor was diagnosed with pancreatic cancer, but insisted he was not as close to death as reports suggested. Despite repeated tabloid claims that his death was imminent, Swayze continued to actively pursue his career.[32]
In early May 2008, it was widely reported in a number of tabloids that Swayze had undergone surgery to remove part of his stomach after the cancer's spread and that he had rewritten his will, transferring his property to his wife.[33][34] In a statement made on May 28, Swayze said he continued to respond well to treatment at Stanford University Medical Center. In late May 2008, he was seen at a Los Angeles Lakers basketball game, his first public appearance since his diagnosis.[35] In 2008 Swayze was treated with Cyberknife radiotherapy cancer treatment.[36]
In late July 2008, six months after reportedly being given just weeks to live by medical experts, a seemingly healthy Swayze was asked by reporter in Los Angeles airport about his health. He replied, "I'm cooking. I'm a miracle dude. I don't know why."[37][38]
Swayze appeared on the ABC, NBC, and CBS simulcast of Stand Up to Cancer in September 2008, to appeal to the general public for donations for the initiative. Swayze said to a standing ovation: "I dream that the word 'cure' will no longer be followed by the words 'it's impossible'. Together, we can make a world where cancer no longer means living with fear, without hope, or worse."[39] After the show ended, Swayze remained onstage and talked to other cancer patients; executive producer Laura Ziskin (herself battling advanced breast cancer, which would claim her own life) said: "He said a beautiful thing: 'I'm just an individual living with cancer'. That's how he wants to be thought of. He's in a fight, but he's a fighter."[39][40] On December 2, 2008, Swayze denied claims made by tabloids that the cancer had spread to his liver.[41]
Swayze told Barbara Walters in January 2009 that he wanted the media to report that he was "kicking it".[42] When Walters asked him if he was using any holistic or alternative methods of treatment besides the chemotherapy, Swayze said he was using some Chinese herbs. He then voiced his opposition to the unsupported claims made by proponents of alternative therapies.
His last role was the lead in an A&E TV series, The Beast, which premiered on January 15, 2009. Owing to a prolonged decline in health, Swayze was unable to promote the series, and in early June the show was canceled due to poor ratings.[43] In an interview with Barbara Walters which aired in January 2009, Swayze admitted that he had a "tiny little mass" in his liver. On January 9, 2009, Swayze was hospitalized with pneumonia. The pneumonia was said to be a complication of chemotherapy for Swayze's cancer.[44] On January 16, he was released from the hospital to rest at home with his wife.[45] On April 19, 2009, doctors informed Swayze that the cancer had again metastasized to his liver.[46] Swayze stated that his chain smoking probably "had something to do with" the development of his disease. Photos taken of a gaunt Swayze in the months before his death showed him continuing to smoke.[47][48] In August 2009, he was hospitalized for a week with intestinal bleeding.
Swayze died, with family at his side, on September 14, 2009, at age 57, 20 months after being diagnosed.[49][50][51] Swayze's publicist confirmed to CNN that he had died of pancreatic cancer.[52] He was cremated, and his ashes scattered over his New Mexico ranch. He was survived by his wife Lisa Niemi, his mother Patsy Swayze, and three siblings.