Sherlock Holmes: I'm not a psychopath, I'm a high-functioning sociopath. Do your research.
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Sherlock Homes: Look at that, Mrs. Hudson. Quiet. Calm. Peaceful. Isn't it hateful?
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John(drunk):Am I....A Vegetable?
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John Watson: There is a mute button and I will use it.
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Irene Adler: Brainy is the new sexy.
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Sherlock Holmes: We've got a serial killer on our hands. Love those, there's always something to look forward to.
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Jim Moriarty: Did you miss me?
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Sherlock Holmes: That's clever. Is it clever? Why is it clever?