A family curse
Fairly obvious.
Origionally from Greek mythology. The story goes:
There once was a king named Lycaeonia who sacrficed meat to the god Zeus. A fairly common occurence in Greece, expect Lycaeonia used human meat. This displeased Zeus, who turned the king into a wolf. The king's name is the origin of the word 'Lycanthrope' and the idea of being turned into a werewolf through curse has been passed through the ages.
The curse could be placed by a sourceror, demon, preist or god.
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How to become a Were Wolf
Hombres LoboNot guaranteed to work, all methods I've found through my curiosity for things like this. Please consider your safety while trying these methods.