Like Magdalene, Cain's properties should be emphasized more. Make it so pills spawn more often than cards and chests spawn more often than keys. It gives Luck Foot and Paper Clip more chance to shine. Could also make Luck-related items more common, like items that affect luck or give luck-based effects, but just making him have the former qualities would be fine too.
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The Binding of Isaac: Repentance Character Overhaul
De TodoI did things with Isaac characters