Velásquez' first movie role was in the film The Untouchable Family. She soon ventured into comedy films. She was cast in the 1988 film Pik Pak Boom. She then co-starred in the flick Elvis and James.
Velásquez' returned to the cinema in 1996 for her first lead role in the film Wanted Perfect Mother. Also in that same year, she was one of three lead actresses in the musical comedy DoReMi alongside Donna Cruz and Mikee Cojuangco. Despite being part of the movie, Velásquez' vocals were not part in recording of the movie's soundtrack, as it was an then-upcoming VIVA Records singer named Krystine, who sang vocals on her part. In the movie version, Velásquez was able to record her vocals just in time before the movie was released.
In 1998's Honey Nasa Langit Na Ba Ako, she played a ghost who died in a car accident days before her wedding day. Also, Velásquez co-starred with Aga Muhlach in the romantic film Dahil May Isang Ikaw. Later, in 2000, she starred in Kailangan Ko'y Ikaw with Robin Padilla. In 2001 she starred in Pangako Ikaw Lang which earned her a Box-Office Queen award from the Guillermo Mendoza Memorial Scholarship Foundation.
In 2002, she won her first Best Actress award from Star Awards (for Television) in her portrayal of a mentally-challenged woman seeking acceptance and love in a Maalaala Mo Kaya episode entitled "Lobo". To date, Lobo is still the highest-rating episode (47.9%) in the history of Maalaala Mo Kaya.
Velásquez acted in two more romantic films in 2002 and 2003; Ikaw Lamang, Hanggang Ngayon and Pangarap Ko Ang Ibigin Ka. In December 2003, she appeared in Captain Barbell.
Velásquez returned to the romance genre in 2006 and 2007 with Till I Met You and Paano Kita Iibigin. In June 2008, she was the voice of Urduja in the animated film Urduja.
In 2009, Velásquez conceptualized the story for OMG (Oh, My Girl!) and she will appear in a cameo role as a production assistant.
In 2012, Velásquez' comeback in the movie scene again is her third movie team-up with Aga Muhlach, Of All the Things, under Viva Films. The film was shown over 120 theaters nationwide and earning 15 million in opening day. It was her reunion movie with Aga after their blockbuster films, Dahil May Isang Ikaw and Pangako Ikaw Lang will be aired in cinemas soon. Meanwhile, it's yet unknown if her indie film, Mrs. Recto, under the direction of Director Dante Nico García, will still be available in cinemas because the shooting of the said film is not yet finished due to Velásquez' long break from showbiz.
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Who Is Regine Velasquez???
FanfictionGaling din po ang impormasyong ito sa Google... #RVF