Eighteen years ago, Zara LaRosa and Dante Salvatori used to play together as often as their parents allowed them to. One night, everyone in the LaRosa family home was killed, except little Zara who managed to escape with the head of her father's security. She was taken to a safe house near Venice, an underground complex where she spent the last 18 years preparing for the moment when she will get revenge for her family's death and destroy the Salvatori family who were the culprits of the tragedy. But Bonifacio Salvatori, the man who ordered her parent's execution is now dead, and his son Dante has become Don and taken over the mafia. Zara resurfaces and starts operating from the shadows, killing Bonifacio's people who were involved in her home invasion and who are now loyal to Dante, earning a nickname Regina del Sangue (Queen of Blood) in the process. Her true identity is unknown to everyone except for her team from the underground and she intends to keep it that way. Will Zara be able to destroy Dante while hiding her identity from him and before he manages to kill her for taking out his people?