The program sends Dan to a city called Townsville and was staying with a man named Professor Utonium and while Dan was staying there he notices that this town has a lot of problems and so the Professor tells Dan that he has an idea to make the perfect little girl to help this town. And Dan becomes curious about it that he decides to try himself. And when it happens the Professor creates 3 girls. And Dan creates 2, a boy and a girl. At first the town hates them, but when trouble happens it's up to these 5 kids to save the day from an army of monkeys.