1) Delirium
- disturbance in attention and awareness
- develops over a short period of time
- additional disturbance in cognition
- rule out: evolving neurocognitive disorder, coma
- evidence in medical history, physical examination, substance intoxication, etc.
a. Substance Intoxication Delirium
b. Substance Withdrawal Delirium
c. Medication-Induced Delirium
d. Delirium due to another Medical Condition
e. Delirium due to Multiple Etiologies
f. Other Specified and Unspecified Delirium
2) Major and Mild Neurocognitive Disorders
a. Major Neurocognitive Disorder
- significant cognitive decline from previous level of performance in one or more cognitive domains
- cognitive domain interfere with independence in everyday activities
- rule out: delirium, another mental disorder
- specify whether due to; alzheimer's disease, frontotemporal lobar degenaration, lewly body disease, vascular disease, traumatic brain injury, substance medication use, HIV infection, prion disease, partkinson's disease, huntington's disease, another medical condition, multiple etiologies, unspecified
b. Mild Neurocognitive Disorder
- modest cognitive decline from previous level of performance in one or more cognitive domains
- cognitive deficits do not interfere with capacity for independence in everyday activities.
- rule out: delirium, other mental disorders
- specify whether due to; alzheimer's disease, frontotemporal lobar degenaration, lewly body disease, vascular disease, traumatic brain injury, substance medication use, HIV infection, prion disease, partkinson's disease, huntington's disease, another medical condition, multiple etiologies, unspecified
3) Major or Mild Neurocognitive Disorder Due to Alzheimer's Disease
- major and mild criteria met
- insidious onset and gradual progression of impairment
- rule out: cerebral palsy, neurodegenerative disease, effects of substance, other mental or neurological disorder
4) Major and Mild Frontemporal Neurocognitive Disorder
- major and mild criteria met
- disturbances on behavioral variant
- language variant
- sparing of learning and memory and perceptual-motor function
- rule out: cerebrovascular disease, neurodegenerative disease, other mental and neurological disorder
- diagnose if or if not: genetic mutation from either family history or genetic testing, disproportionate frontal and temporal lobe from neuroimaging
5. Major or Mild Neurocognitive Disorders with Lewy Bodies
- major or mild criteria met
- insidious onset and gradual progression
- probable major or mild; 2+ core features or 1 suggestive features
- possible major or mild; 1 core features, 1+ suggestive features
- rule out: cerebrovascular disease, neurodegenerative disease, effects of substance, other mental, neurological or systemic disorder
a. Core Diagnostic Features
- fluctuating pronounced variations in attention and alertness
- recurrent visual hallucination
- features of parkinsonism
b. Suggestive Diagnostic Feature
- rapid eye movement / sleep criteria met
- severe neuroleptic sensitivity
6) Major or Mild Vascular Neurocognitive Disorder
- major or mild criteria met
- consistent with a vascular etiology
- complex in attention (processing speed) and frontal executive function
- evidence of the presence of cerebrovascular disease from history, account to neurocognitive deficits
- rule out: another brain disease or systemic disorder
7) Major or Mild Neurocognitive Disorder Due to Traumatic Brain Injury
- major or mild criteria met
- evidence of traumatic brain injury, rapid movement or displacement of the brain; loss of consciousness, posttraumatic amnesia, disorientation and confusion, neurological signs
8) Substance / Medication-Induced Major or Mild Neurocognitive Disorder
- major or mild criteria met
- do not occur during delirium and persist beyond the duration of intoxication and acute withdrawal
- consistent with the timing of substance and medication use
- rule out: another mental disorder
9) Major or Mild Neurocognitive Disorder Due to HIV Infection
- major or mild criteria met
- there is a documented infection with HIV
- rule out: non-HIV conditions, another medical or mental disorder
10) Major or Mild Neurocognitive Disorder Due to Prior Disease
- major or mild criteria met
- insidious onset, rapid progression of impairment
- motor features; prion disease, myoclonus, ataxia, biomarker evidence
- rule out: another medical or mental disorder
11) Major or Mild Neurocogntive Disorder Due to Parkinson's Disease
- major or mild criteria met
- occurs in the setting of Parkinson's disease
- insidious onset and gradual progression of impairment
- rule out: another medical or mental disorder
12) Major or Mild Neurocognitive Disorder Due to Huntington's Disease
- major or mild criteria met
- insidious onset and gradual progression of impairment
- established Huntington's disease
- rule out: another medical or mental disorder
13) Major or Mild Neurocognitive Disorder Due to Another Medical Condition
- major or mild criteria met
- pathophysiological consequence of another medical condition
- rule out: another mental or neurocognitive disorder
14) Major or Mild Neurocognitive Disorder Due to Multiple Etiologies
- major or mild criteria met
- pathophysiological consequence findings of more than one etiological process except substances
- rule out: another mental disorder, during delirium
