Schizophrenia: Causes, Characteristics and Treatments

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Schizophrenia: Causes, Characteristics  and Treatments

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Learning Outcomes:

By the end of this session, you should be able to

Describe the symptoms associated with a diagnosis of schizophrenia

Discuss some of the challenges associated with making a clear diagnosis

Evaluate the different causes of schizophrenia

Describe different treatment methods and their efficacy


History and Controversies 

1883 – Kraepelin first proposed a diagnosis of "Dementia Praecox"

- Progressive and deteriorating illness with no return to the previous functioning

1908 – Bleuler developed four symptom model:

- Ambivalence

- Disturbance of association

- Disturbance of mood

- Preference for fantasy over reality

One of these symptoms on its own wouldn't really be seen as schizophrenia – but when multiple symptoms are shown to be enduring that's when it's diagnosed

Remains a controversial topic:

- Does schizophrenia exist as a distinct state?

- Does it originate from genetic, biological or environmental causes

- Should it be treated by drug therapy, ECT or social and psychological therapies?

- Not sure what the single most effective course of action of schizophrenia – mystery in its treatment that makes it controversial


Symptoms

Diagnostic and statistical manual of mental disorders

(DSM-5):

- Delusions

- Hallucinations

- Disorganised speech – or sign if deaf

Grossly disorganised behaviour or catatonic behaviour – catatonia is a motor disorder where the limbs become stiff and experience more flexibility – related to the motor cortex. Does not manifest as frequently as it used to – people from South Asia experience catatonia more though unknown why

Negative symptoms: e.g. flattened mood, avolition (lack of normal functioning – an absence of function)

Diagnosis involves the presence of symptoms, but also impairment of social or occupational functioning

Criterion A (positive symptoms)

- Delusions (persecutory, referential, somatic, religious, grandiose)

- Hallucinations (auditory, visual, olfactory, gustatory and tactile)

- Disorganised speech (derailment, tangentiality or word salad)

- Grossly disorganised behaviour (e.g. childlike silliness, unpredictable agitation, difficulties with daily tasks or routines, dishevelled or unusual appearance, inappropriate behaviour)

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