Amy Poheler as Joy
Maya Hawke as Anxiety
Joan Cusack as Maya
Jeremy Clyde as himself
Phyllis Smith as Sadness
Bill Hader as Fear
Lewis Black as Anger
Mindy Kaling as Disgust
Ayo Edebiri as Envy
Adèle Exarchopoulos as Ennui
Paul Walter Hauser as Embarrassment
Estelle Getty as Meemaw
Chad Stuart as his angel
Sophie Zamchick as Linny
Teala Dunn as Tuck
Danica Lee as Ming-Ming
Paul McCartney as his video game avatar
Sarah Jessica Parker as Momma
Kyle Secor as Daddy
June Squibb as Nostalgia
Imelda Staunton as the headmistress
Bonnie Wright as Amanda
Abbi Carter as Hermina
Mel Blanc as the mind workers and the mind police
