Bo Hughes is a hardheaded, proud girl from Chicago, Illinois, who's forced to leave everything she knows for the sake of her mother's new job at a laboratory in Hawkins, Indiana. Making friends isn't difficult for Bo, with her stunning beauty and flirty charm, but one boy, in particular, Billy Hargrove, presents her with a challenge. With a boyfriend back home in Chicago, Bo befriends Billy, despite the constant sexual tension between them. Navigating this more-than-complicated friendship while also fighting supernatural monsters in a town with many secrets was not what Bo thought her senior year was going to look like. Will they end up together? Will both of them survive?