Splinter, the rat sensei, senses something amiss in New York City. His disciples, Leonardo, Donatello, Raphael, and Michelangelo have grown apart since their last adventure the final defeat of their archenemy, the Shredder. Shredder's students Jesse, Jamey, Tasneem, and Cheyenne join the brothers after seeing that they can become heroes like the brothers. After a few days of staying with the brothers while getting to know them more, each sister started to fall for one of the brothers. Jamey and Raph started dating, and Cheyenne and Donnie started dating a few days before Jamey and Raph started. Mikey and Tasneem started dating sometime after them and finally, Jesse and Leo started after them. When Leonardo comes home from his long venture, there is an immediate strain on his relationship with Raphael while mysterious Foot Clan activity and monster sightings cause additional difficulty. The teenage terrapins must somehow renew and strengthen their bond if they are to have any hope of defeating an evil industrialist's army of ancient monsters.